New and Used Industrial Plants

190 Acre API Manufacturing Plant ComplexGrimsby, England, UK

This world-class, fully integrated API manufacturing site, formerly operated by Novartis, includes over 1,200m3 of total reactor vessel capacity across three distinct production buildings, available for sale or lease as a whole site or individual buildings for operation in-place. The facility could be utilized for pharmaceutical and animal health API manufacturing or repurposed for specialty/fine chemical manufacturing, flavors and fragrances, or agrochemicals.

Take the 360° Tour:

Building 110, Former Novartis Site, Grimsby

Building 150, Former Novartis Site, Grimsby

VIDEO: https://www.youtube.com/watch?v=AUWUHnAyWos&list=PLRlhdb05DXKR4eyHsLOkB6NzTyh2R4YCE

The site is located adjacent to the river Humber and between the Immingham and Grimsby port facilities, less than 5 minutes from downtown Grimsby, 25 minutes from Humberside Airport, 2.5 hours from Manchester Airport, 3.5 hours from London Heathrow.

Inside the fenceline is approximately 100 acres, with significant development land and infrastructure available inside the fence. There is an additional approximately 90 acres of agricultural land outside the fenceline.

Facility has the capabilities to perform various chemical synthesis, including hydrogenation, Grignard/Friedel-Crafts Reactions, Azide, and Tin Chemistries.

Building 110: Multi-product, Multi-purpose facility (ca. 1993)

• Total Reactor Capacity: 140m3
• Hydrogenation, Crystallization, Centrifugation, Nutsche Filters, Short-Path Distillation, Milling/Blending, Solvent Recovery
• Overhead manifolds and flex piping for production flexibility
• Glass Lined, Hastelloy, and Stainless Steel Equipment

Building 120: Mixed High Volume, Multi-Purpose Facility (ca. 1994/2007)

• Total Reactor Capacity: ~450m3
• 3 dedicated, 3 multi-purpose lines-Hydrogenation, Crystallization, Sublimation, Nutsche Filters, Paddle Dryers, Milling/Blending, Solvent Recovery
• Glass Lined, Hastelloy, and Stainless Steel Equipment

Building 150: High Volume, Multi-Product Facility (ca. 2004/2007)

• 4 Dedicated Process Trains
• Total Reactor Capacity: ~550m3
• Hydrogenation, Crystallization, Centrifugation, Drying, Milling/Blending, Solvent Recovery
• Glass Lined, Hastelloy, and Stainless Steel Equipment

Each building has its own dedicated solvent storage and recovery, in-process lab spaces, workshops, and offices.

Site Utilities:

• 2400m3/day Wastewater (Effluent) Treatment Facility
• 2x4.2MVA grid electricity
• 8000m3/h compressed air
• 3000m3/h nitrogen (by pipeline)
• 4x8MW cooling water capacity
• Towns Water potable supply & 400m3/day borehole (well) water for process cooling
• Previously, there was a CHP plant which has been removed and steam boilers will need to be added to support operations.

The production buildings are supported by the following non-production infrastructure:

• Security Facility
• Administrative Office Building
• 4600m2 (50,000ft2) Engineering Workshop and Offices to support major projects, MRO stores, fabrication, equipment and instrument maintenance, etc.
• 3700m2 (40,000ft2) Lab/R&D Space with sample retain storage facility
• Restaurant/Canteen Building
• Medical Facility/Employee Welfare
• Sports Club and Fields
• Capital Good Stores
• Changeover Warehouses

Warehousing:

• Raw Materials & Intermediate Storage: 3000 pallets
• Solvent (flammable & hazardous) Warehouse: 1930 pallets
• Packaging Storage: 500 pallets
• Finished Goods Storage: 750 pallets
• Cold Storage (-8 deg. C): 320 pallets
• Classified area for sampling / repacking of raw materials: 40 pallets
• Waste Storage: 1200 pallets

The facility was not used in production of of plant/animal extracts, fermentation, penicilin, beta-lactams, steroids, hormonals, or cytoxic compounds.

The polymerization plant (PPU) has a capacity of 225,000 tons per year and is a Unipol technology plant, with two gas phase reactors, so can produce homopolymers, random copolymers and impact copolymers.

The extruder is a Coperion ZSK300, with a 5.5MW Loher main motor and associated transformer. The extruder also has a Maag polymer pump, Gottfert on-line rheometer, and electric hot oil systems for the die plate and barrel.

There are six, 280t capacity pellet silos downstream of the extruder, three with air spinner container loading spouts.

There are also another 280t silo, one 140t silo and three 70t silos.

There are also six air blowers for the dilute phase conveying of the pellets from the extruder to the silos or between silos.

There are also two Atlas Copco GA132 compressors to drive the air spinners and silo purging.

There is also a Refinery Grade Propylene (RGP) purification system which includes a Propylene Treatment Plant (PTP) which contains alumina bed driers, a de-ethaniser column, and a de-butaniser column. The PTP supplies treated RGP to a propane-propylene splitter (PPS). The PPS is a heat pump design for minimum utilities demand.

The PTP has a RGP feed capacity of 26 t/hr, whilst the PPS has an RGP feed capacity of 16 t/hr at 70% propylene to produce 11 t/hr polymer grade propylene (PGP) at 98% recovery and 99.0% purity.

The PPU, extruder and PPS were commissioned in September 1991.

The PTP was commissioned in April 1995.

There is a fibre glass cooling water tower comprised of four 15MW cells and three 450kW water circulation pumps. This was commissioned in October 2010.

1.2 Propanediol (Propylene Glycol) Continuous Hydrogenation System

Process Steps: -Continuous Hydrogenation -Evaporation -Distillation

Major Equipment: -500 mm dia. x 20 M SS Packed Column -(8) Glass Reactors: 1,200 Liter to 12,500 Liter -(6) SS Reactors: 7,200 Liter to 24,000 Liter -(2) Basket Centrifuges